To examine connectivity anywhere between diet and coronary attack, we utilized Cox proportional dangers patterns stratified because of the decades (mo) and you can pursue-up course in order to estimate RRs and you may 95% CIs. People had been divided in to quintiles from collective average intake away from magnesium, potassium, and you can calcium supplements to minimize the interior-individual adaptation and best portray a lot of time-name intake ( 18). A combined nutrient diet get off magnesium, potassium, and you can calcium supplements have been computed of the assigning factors to for every quintile and summing the latest products. Members regarding the low quintile (quintile step one) of magnesium, potassium, otherwise calcium consumption received 1 part each mineral, participants next quintile (quintile dos) received dos products, an such like. Cumulative averages were calculated by taking the new mean of all stated FFQ intakes to the start of per 2-y realize-upwards period. Brand new cumulative average intake was utilized to help you assume coronary attack occurrence out-of the amount of time of one’s history came back questionnaire till the second go after-upwards cycle.
Multivariate designs was in fact modified to possess many years (mo) and calendar day (2-y date periods) and you can included intakes away from total opportunity (kcal), alcoholic drinks (g/d), tobacco, Bmi, physical activity, parental reputation for very early myocardial infarction, postmenopausal hormone medication have fun with, thiazide explore, aspirin fool around with, multi vitamin play with, and you will history of diabetic issues, blood pressure, and you will hypercholesterolemia at the standard. To check having good linear trend, we assigned for every quintile new median value and you will modeled so it adjustable just like the a continuous changeable. We checked the possibility deviation of linearity by using a probabilities ratio decide to try having comparison out-of a model with the linear title that have a model like the linear identity and additionally minimal cubic spline changes ( 19). We including presented analyses you to definitely included all the step 3 nutritional elements on top of that. Magnesium and you will potassium consumption was indeed very correlated (roentgen = 0.79 on the NHS We; r = 0.73 throughout the NHS II), and you will correlations between calcium supplements and potassium intakes (roentgen = 0.forty-two in the NHS I; roentgen = 0.41 regarding the NHS II), whereas ranging from calcium and you can magnesium consumption (r = 0.54 from the NHS I; roentgen = 0.56 throughout the NHS II) had been modest. The new Q shot was used to check into heterogeneity anywhere between the latest NHS We and NHS II. RRs (±SEs) per quintile out-of for each and every cohort had been pooled in fixed-consequences habits to assess realization estimates ( 20). Likewise, the brand new current meta-study accompanied basic behavior ( 20) regarding assessment to possess heterogeneity using the Q test and having fun with fixed consequences model to help make conclusion quotes whenever zero between-degree heterogeneity was obvious; if not a random-consequences model was utilized.
To examine the potential effect modification of the association between dietary minerals and stroke risk by age, hypertension, and diabetes, we stratified our multivariate model on age (<60 compared with ?60 y), hypertension (yes compared with no), and diabetes (yes compared with no) and separately tested the significance of an interaction by using a likelihood ratio test for the comparison of the model with interaction terms to the model with only main effects. All P values were 2-sided, and analyses were conducted with SAS 9.2 software (SAS Institute Inc.).
During the 29 y away from realize-upwards of 1980 compliment of 2010 about NHS I and you can twenty two y away from pursue-right up out of 1989 owing to 2011 on NHS II, all in all, 3780 incident heart attack instances was in fact determined. Of those cases, 3237 event shots was recorded about NHS I (plus 1664 ischemic, 544 hemorrhagic, and 1029 unspecified shots), and you can 543 experience strokes had been recorded regarding NHS II (and additionally 186 ischemic, ninety five hemorrhagic, and 265 unspecified shots). Age-standardized functions off data users during the midpoint through the follow-right up during the 1994 into the NHS I along with 1995 to possess the newest NHS II are given in Desk step 1. Ladies with large mineral intake was indeed likely to have fun with aspirin, multivitamins, and postmenopausal hormonal therapy, so much more yourself effective, less likely to end up being current cigarette smokers than simply had been girls having straight down mineral intake. Studies for women on NHS We and you may NHS II was indeed shared just like the we didn’t observe a life threatening between-data heterogeneity (Q-fact P > 0.05).